Drug Discovery, Development and Delivery Core (D4 Core)

Therapeutic Approaches: Biologics, Small Molecules, Biomarkers, Drug Delivery

Therapeutic Areas of Expertise: Immunology, Infectious Diseases

Center/Program Highlights:The Drug Discovery, Development and Delivery Core provides investigators with access to technological expertise enabling biochemical (100,000+ compounds), natural product and siRNA library screening. The core currently houses the instrumentation and robotics used in traditional MTS (medium throughput screening) for next-generation small-molecule discovery research and cell-based analysis, and partners with an HTS ready facility. The D4 core is a collaboration involving many on-site facilities such as the organic synthesis core for drug development and hit-to-lead optimization and the imaging core for nanotech drug delivery characterizations. We are a conveniently located centralized facility providing a ?one stop shop? to fully realize your drugs potential through: ?High-throughput screening of chemical libraries ?Developing drug delivery formulations (i.e nanotechnology, liposome formulations) ?Pharmacokinetic and pharmacodynamic studies The core collaborates with investigators to discover chemical agents that affect cellular targets involved in human diseases, to increase opportunities for successful grant funding, and to avoid high cost and time investment needed to train lab personnel. Considerations for using the D4 core should be given by anyone who has a drug target (receptors, genes, proteins, siRNA, etc.) or has a drug compound ready to test, wants to explore opportunities for drug development related to their research or wants to investigate the use of nanotechnology as a method for drug delivery.

Sources of Funding: Federal/State, University


Institutional Affiliation(s): Penn State College of Medicine

500 University Drive
Pennsylvania, 17033
United States

Center/Program Start Date: 2002

Number of Employees: 2